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Articles from Thomas Schmitt | Selfgrowth.com
- The Synthesis of Nanoparticles You Don't Want to Miss - by Submitted on Nov 01, 2021 from Thomas SchmittNanoparticle synthesis refers to methods for creating nanoparticles. Nanoparticles can be derived from larger molecules, or synthesized by ‘bottom-up’ methods that, for example, nucleate and grow particles from fine molecular distributions in liquid or vapour phase. Synthesis can also include ...
Views: 392 - What Are Melamine Resin Particles? - by Submitted on May 24, 2022 from Thomas SchmittMelamine (1, 3, 5-triamino-2, 4, 6-triazine) resin, or melamine formaldehyde (MF) is one of the hardest and stiffest thermosetting polymers, which provides good properties and performance. It is an amino resin and has various material advantages, such as transparency, better hardness, thermal ...
Views: 392 - Researchers Learn That Non-toxic Concentration of Silver Nanoparticles Can Antagonize Arsenic-induced Genotoxicity - by Submitted on Apr 01, 2021 from Thomas SchmittRecently, a research team found that non-toxic concentrations of silver nanoparticles can antagonize the genotoxicity induced by arsenic by reducing the bioaccumulation of heavy metal arsenic in mammalian cells and enhancing the anti-oxidant ability in the cells. Related research results were ...
Views: 391 - What is Antibody KD - by Submitted on Jul 23, 2021 from Thomas SchmittIn chemistry, biochemistry, and pharmacology, the dissociation constant (KD) is a specific type of equilibrium constant used to measure the tendency of larger objects to reversibly separate (dissociate) into smaller components, such as When the complex decomposes into its component molecules or ...
Views: 391 - A Quick Review of Cell Isolation & Organelles Isolation - by Submitted on Sep 22, 2021 from Thomas SchmittWhat is organelles isolation? The separation of organelles is achieved by cell membrane lysis and density gradient centrifugation to separate organelles from contaminated cell structures. The intact nucleus and organelles have a unique size in mammalian cells, allowing them to be separated by ...
Views: 388 - Neuropilin-1 Promotes SARS-CoV-2 Entry into Host Cells - by Submitted on Apr 01, 2021 from Thomas SchmittThe 2019 Coronavirus Disease (COVID-19) caused by the new coronavirus SARS-CoV-2 is now raging around the world. Existing studies have shown that SARS-CoV-2 infects host cells through the receptor ACE2. In a new study, scientists discovered that neuropilin 1 (NRP1) is a factor that can promote ...
Views: 385 - Liposomes for DNA/RNA Delivery - by Submitted on Jun 24, 2021 from Thomas SchmittLiposomes are vesicular structures, and the unique advantages imparted by lipid vesicles are their diverse range of morphologies, compositions, abilities to envelope and protect many types of therapeutic biomolecules, lack of immunogenic response, low cost, and their differential release ...
Views: 383 - What Are Melamine Resin Particles? - by Submitted on Feb 01, 2023 from Thomas SchmittMelamine (1, 3, 5-triamino-2, 4, 6-triazine) resin, or melamine formaldehyde (MF) is one of the hardest and stiffest thermosetting polymers, which provides good properties and performance. It is an amino resin and has various material advantages, such as transparency, better hardness, thermal ...
Views: 381 - What Are D-Glucosamines? - by Submitted on Jun 13, 2022 from Thomas SchmittGlucosamine is a natural component of cartilage and is widely used as an over-the-counter nutritional supplement to reduce the pain and cartilage loss of osteoarthritis. Glucosamine is usually taken in combination with chondroitin, which is a glycosaminoglycan that also exists in ...
Views: 380 - Why does Immunotherapy Have No Effect on Certain Tumors - by Submitted on Jun 01, 2021 from Thomas SchmittAs we all know, tumor tissue is not only composed of cancer cells, it also contains other types of cells. These other cell types can affect tumor behavior and have a profound impact on whether the tumor will respond to therapy, including immunity therapy etc. Fibroblasts are distributed ...
Views: 374 - Chemical Medicine Lung Inhalation Nano Preparation - by Submitted on Dec 02, 2021 from Thomas SchmittAt present, a variety of chemical drugs are combined with nano-carriers to make lung-inhaled nano-preparations, and have achieved good results, such as anti-tuberculosis drugs, itraconazole, terbutaline sulfate, ciprofloxacin, curcumin and Camptothecin. Anti-tuberculosis drugs Polylactic ...
Views: 368 - The Switch to Burn Fat-IL-27 - by Submitted on Mar 23, 2022 from Thomas SchmittObesity refers to a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. Excessive food intake or changes in the body’s metabolism lead to excessive accumulation of fat in the body, resulting in ...
Views: 368 - What Are Nano Secondary Antibodies - by Submitted on Sep 22, 2021 from Thomas SchmittAntibodies are biological protein molecules that are produced by immune B cells after being stimulated by antigens that can specifically bind to the antigen, and then neutralize the antigen. Because antibodies can specifically bind antigens with high affinity, antibodies have always been one of ...
Views: 367 - What are Strongyloides? - by Submitted on May 24, 2022 from Thomas SchmittStrongyloides is an opportunistic pathogenic parasitic nematode. Adults parasitize in the small intestine of cats, dogs and humans. The larvae can invade lung, brain, liver, kidney and other tissues and organs, causing strongyloidiasis. The disease is mainly prevalent in warm and humid tropical ...
Views: 367 - What Is Chitosan? - by Submitted on Apr 23, 2021 from Thomas SchmittChitosan is the second most abundant biopolymer in the world, only less than cellulose. It is a versatile biopolymer with unique properties, and is nontoxic, biodegradable and biocompatible. Chitosan is discovered by Rouget in 1859, when the chitin was treated with hot potassium hydroxide ...
Views: 363 - What Are D-Glucosamines? - by Submitted on May 24, 2022 from Thomas SchmittGlucosamine is a natural component of cartilage and is widely used as an over-the-counter nutritional supplement to reduce the pain and cartilage loss of osteoarthritis. Glucosamine is usually taken in combination with chondroitin, which is a glycosaminoglycan that also exists in ...
Views: 362 - Application of Polyethylene Glycol (PEG) in the Medical Field - by Submitted on Jan 27, 2022 from Thomas SchmittThe chemical structure of polyethylene glycol (PEG) is HO-(CH2CH2)n-OH, which is a general term for ethylene glycol polymers with a relative molecular mass of 200 to 8000 and above. Polyethylene glycol is the polymer with the lowest level of absorption by proteins and cells among the known ...
Views: 360 - What Role Does Gold Nanorod Play in Cancer Treatment? - by Submitted on Jun 01, 2021 from Thomas SchmittGold nanorods (AuNRs) are gold nanoparticles with a specific morphology in the range of 1 to 100 nm. They present two distinct SPRs on the transversal axis and the longitudinal axis. Longitudinal plasmon resonance can provide absorption of wavelength radiation in the near-infrared region (NIR), ...
Views: 360 - What Are Dextrans? - by Submitted on Feb 28, 2022 from Thomas SchmittDextran is a polysaccharide comprised of d-glucopyranose (d-glucose) repeating units linked through glycosidic linkages. It is biocompatible, biodegradable, and presents antithrombotic and anti-inflammatory properties. Dextran functional hydroxyl (–OH) groups offer an easy point for chemical ...
Views: 359 - What Are Gold Nanorods? - by Submitted on Jan 05, 2022 from Thomas SchmittGold nanorods, as a kind of capsule-like gold nanoparticles with a scale from a few nanometers to hundreds of nanometers, have more peculiar optical properties than spherical gold nanoparticles due to their localized surface plasmon resonance (LSPR) effect. Gold nanorods are biomaterials ...
Views: 357 - What are Metal Nanoclusters - by Submitted on Jan 27, 2022 from Thomas SchmittMetal nanoclusters are a kind of nanomaterials with a size of less than 2 nm and stacked by 1 to 150 metal atoms. Metal nanoclusters have a typical core-shell structure, consisting of a metal atomic core and a ligand molecular shell. Ligands are usually substances that have strong covalent ...
Views: 353 - Nipah Virus Detection Method - by Submitted on Apr 15, 2022 from Thomas SchmittOver the past few decades, there have been multiple outbreaks of viruses causing severe and severe disease around the world, including known and unknown viral pathogens such as SARS-CoV, Ebola, Lassa fever, Marburg virus, Nipah virus, Hendra virus, Rift Valley fever virus and Middle East ...
Views: 349 - Quantum Dots Technology in Fluorescent Labeling - by Submitted on Jul 23, 2021 from Thomas SchmittLiposomes are vesicular structures, and the unique advantages imparted by lipid vesicles are their diverse range of morphologies, compositions, abilities to envelope and protect many types of therapeutic biomolecules, lack of immunogenic response, low cost, and their differential release ...
Views: 349 - What Are Contrast Agents for Computed Tomography? - by Submitted on Aug 24, 2022 from Thomas SchmittComputed tomography, or CT, was developed in 1960s and early 1970s. It refers to a computerized X-ray imaging procedure in which a narrow beam of X-rays is aimed at the patient and rapidly revolves around the body, producing signals that are processed by a machine computer to generate a ...
Views: 349 - EXO-CD24 and the Treatment of COVID-19 - by Submitted on Dec 01, 2021 from Thomas SchmittOne of the characteristics that cancer cells can obtain and maintain in the body is their ability to evade detection and destruction by the human immune system. For example, some tumor cells produce higher-than-normal amounts of protein as a “don’t eat me” signal, which exists on the cell ...
Views: 348 - The New Mechanism of Aging To Promote Cancer - by Submitted on Apr 23, 2021 from Thomas SchmittAs we age, the body will accumulate “garbage” in the body during the process of converting food into energy. Clinical statistics have found that the risk of cancer and related mortality in humans increases significantly with age from the age of 65. Is it because the body’s “junk” substances ...
Views: 348 - Overview of Monkeypox - by Submitted on Aug 24, 2022 from Thomas SchmittMonkeypox is caused by the monkeypox virus. Monkeypox virus is a virus belonging to the genus Orthopoxvirus of the Poxviridae family. Monkeypox virus has the typical shape of Orthopox virus, with a rounded brick shape or an oval shape and a size of 200-400 nm. The virus is enveloped by a ...
Views: 345 - Advantages of Nanoparticles in Transdermal Drug Delivery - by Submitted on Jul 19, 2021 from Thomas SchmittNanoparticles are a kind of nanomaterials with high dispersion characteristics. It can pass through the hair follicle or stratum corneum, thereby improving the transdermal absorption of the drug and the sustained release of the drug, and can protect the drug from degradation. Solid lipid ...
Views: 343 - Difficulties in Research and Development of the Novel Coronavirus Vaccine - by Submitted on Feb 04, 2021 from Thomas SchmittAt present, the outbreak of COVID-19 has spread to more than 200 countries and regions around the world, and the number of confirmed cases has exceeded 6 million. The world is racing to develop the Novel Coronavirus vaccine. Dozens of candidate vaccines are undergoing pre-clinical evaluation, ...
Views: 343 - Sucrose Polymer Overview - by Submitted on Jul 20, 2022 from Thomas SchmittSucrose is a disaccharide with a unique structure. It is a non-reducing sugar formed by removing a molecule of water from the glycoside hydroxyl group of a molecule of α-D-(+)-glucopyranose and a molecule of β-D-(-)-fructofuranose. During the hydrolysis process, the specific optical rotation of ...
Views: 343 - What Are The Influencing Factors of Drug Percutaneous Absorption - by Submitted on Jun 24, 2021 from Thomas SchmittIn the clinical transdermal drug delivery process, there are many factors that affect the transdermal absorption of the drug, mainly including: skin hydration, skin temperature, skin conditions, and skin locations. Skin Hydration The phenomenon that the water content of the skin exceeds the ...
Views: 340 - What Are Gold NanoCages? - by Submitted on Dec 27, 2022 from Thomas SchmittGold nanocages refer to the hollow gold nanostructures with porous walls that were developed by Sun and Xia and Chen et al. in the early 2000s. The hollow and porous structures are synthesized by the galvanic replacement between silver nanocubes and chloroauric acid in aqueous solution. By ...
Views: 339 - Application Research of Natural Hirudin - by Submitted on Mar 23, 2022 from Thomas SchmittHirudin is one of the most significant and most studied active ingredients in leeches and their salivary glands. It is a small molecule protein (polypeptide). Leeches are rich in hirudin, which has a strong inhibitory effect on thrombin and is the strongest natural specific inhibitor of thrombin ...
Views: 337 - Overview of Brucella Abortus - by Submitted on Oct 31, 2022 from Thomas SchmittBrucellosis is a zoonotic infectious disease caused by Brucella, and it is one of the most widespread zoonotic diseases in the world, which brings great losses to the animal husbandry industry. Here, we will outline several aspects about the pathogen, living environment, identification, and ...
Views: 337 - What are AMOTs? - by Submitted on May 08, 2023 from Thomas SchmittAMOT family, also known as the Motin family, has three members: angiomotin (AMOT), angiomotin-like protein 1 (AMOTL1), and angiomotin-like protein 2 (AMOTL2). There are two shear isomers of AMOT, AMOT-P130 and AMOT-P80. AMOT was first discovered and named in 2001. Existing studies have shown ...
Views: 337 - A Few Tips To Better Know About Neutral Lipids - by Submitted on Jan 05, 2022 from Thomas SchmittWhat Are Neutral Lipids? Neutral lipids are defined as hydrophobic molecules lacking charged groups. Neutral lipids, such as cholesteryl ester (CE), triacylglycerol (TAG), and wax ester (WE), provide organisms with inert forms of energy used in conditions of nutrient deprivation and ...
Views: 334 - Experts Find New Details about How Immune System Builds Long-term Memory - by Submitted on Jan 05, 2022 from Thomas SchmittRecently, some experts have identified an essential part of the long-term memory of the immune system, providing useful new details for the design of better vaccines that are suitable for many diseases from COVID-19 to malaria. This new study, published in the Journal of Experimental Medicine, ...
Views: 333 - Cancer Target: Mesothelin - by Submitted on Feb 01, 2023 from Thomas SchmittMesothelin is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein. Its biological function has not yet been clarified, but due to its limited distribution in normal tissues and high expression in some tumor tissues, it is expected to be used in tumor-specific treatment. In ...
Views: 330 - Metal-organic Frameworks and Novel Drug-Carrying Systems - by Submitted on Aug 24, 2022 from Thomas SchmittMetal-organic frameworks (MOFs) form long-range ordered geometric structures through the coordination and binding of metal ions and small organic molecules, changing metal elements and small organic molecules, resulting in an ever-expanding family of MOFs. Due to their excellent properties such ...
Views: 329 - Why does Immunotherapy Have No Effect on Certain Tumors - by Submitted on Oct 23, 2021 from Thomas SchmittAs we all know, tumor tissue is not only composed of cancer cells, it also contains other types of cells. These other cell types can affect tumor behavior and have a profound impact on whether the tumor will respond to therapy, including immunity therapy etc. Fibroblasts are distributed ...
Views: 329 - A Review of Proteolytic Targeting Chimeras - by Submitted on Apr 03, 2023 from Thomas SchmittThe concept of proteolytic targeting chimera (PROTAC) was first proposed by Crews and Deshaies laboratory in 2001, the team successfully achieved the degradation of methionyl aminopeptidase 2 (MetAp-2) by PROTAC method. Since then, PROTACs targeting androgen receptor (AR) and estrogen receptor ...
Views: 328 - What Are Iron Oxide Nanoparticles? - by Submitted on Oct 31, 2022 from Thomas SchmittIron oxides are common compounds, which are widespread in nature and can be readily synthesized in the laboratory. Iron oxide nanoparticles (NPs) typically refer to the materials that consist of magnetite (Fe3O4) or maghemite (γ-Fe2O3) and have a size ranging from 1 to 100 nm. These ...
Views: 327 - What Is Polylactide? - by Submitted on Aug 18, 2023 from Thomas SchmittPolylactide (PLA), also the polylactic acid, is the biodegradable hydrolyzable aliphatic semicrystalline polyester that can be produced through the direct condensation reaction of its monomer, lactic acid, as the oligomer, and also by a ring-opening polymerization of the cyclic lactide ...
Views: 327 - Advantages of Nanoparticles in Transdermal Drug Delivery - by Submitted on Jul 19, 2021 from Thomas Schmittanoparticles are a kind of nanomaterials with high dispersion characteristics. It can pass through the hair follicle or stratum corneum, thereby improving the transdermal absorption of the drug and the sustained release of the drug, and can protect the drug from degradation. Solid lipid ...
Views: 326 - Researchers Stabilize the Collapsing Metal-organic Frameworks by Adding a Polymer - by Submitted on Apr 23, 2021 from Thomas SchmittHigh internal surface area is a highly sought after asset in material design, bringing metal-organic frameworks (MOFs) at the forefront of materials research. In fact, the main focus in this field is to create innovative methods to maximize the surface area of the MOF. Nevertheless, macroporous ...
Views: 326 - Carrageenans as a Versatile Tool in Drug Delivery - by Submitted on May 08, 2023 from Thomas SchmittDrug delivery is the process of administering pharmaceutical substances to targeted areas in the body. It plays a vital role in the effective treatment of various diseases. However, drug delivery is often challenged by the body’s natural defenses, such as the gastrointestinal tract and the ...
Views: 325 - Introduction to Measles Virus - by Submitted on Sep 27, 2022 from Thomas SchmittMeasles virus (MV) is the causative agent of measles in children. Measles is a highly contagious infectious disease. According to the World Health Organization, about 20 million children worldwide suffer from measles every year. Measles virus is highly contagious and has high morbidity. In ...
Views: 323 - What is Nano Dressing? - by Submitted on Oct 30, 2023 from Thomas SchmittNanotechnology has not only received attention and applications in the field of drug delivery, but also has achieved many successes in the field of tissue engineering. Nano dressings can be defined as dressings in which nanomaterials are the matrix. The birth of nano dressings has brought new ...
Views: 323 - Advantages of Liposomal in Drug Delivery - by Submitted on Nov 29, 2022 from Thomas SchmittLiposomes are ultra-micro spherical carrier preparations formed by lipid bilayers, and are typical representatives of nano-drug delivery systems. When amphiphilic molecules such as phospholipids are dispersed in the aqueous phase, the hydrophobic tails of the molecules gather together, and the ...
Views: 321 - Study on Recombinant Hirudin - by Submitted on Jun 13, 2022 from Thomas SchmittAlthough natural hirudin is in great demand in clinical and pharmaceutical research, it is not easy to obtain. With the gradual exhaustion of natural leech resources, the gap between supply and demand is expanding year by year. In order to alleviate the shortage of leech resources, researchers ...
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