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Articles from Jerry Carter | Selfgrowth.com
- Up-to-date Progress in the R&D of Anti-influenza Vaccines - by Submitted on Apr 28, 2021 from Jerry CarterInfluenza is a respiratory infectious disease caused by the influenza virus. About 5% to 10% of people in the world are infected with influenza every year. According to the scale, influenza epidemics can be divided into influenza pandemics and seasonal influenza epidemics. There are four main ...
Views: 328 - Clinical Progress of Anti-SARS-CoV-2 Neutralizing Antibody (NAb)—PART I - by Submitted on Apr 28, 2021 from Jerry CarterCurrently, the number of COVID-19 confirmed cases has exceeded 147 million, and the death exceeded 2 million. The rapid spread of COVID-19 prompts the healthcare community to explore potential treatments, by investigating the drugs that are already approved and developing innovative therapies ...
Views: 326 - New discovery on cancer cell membrane makes it possible to inhibit cancer cell proliferation! - by Submitted on Aug 03, 2021 from Jerry CarterThe development of new cancer therapy is based on the discovery of new characteristics and weaknesses of cancer cells. A group of Danish researchers found another characteristic of cancer cells through experiments on cancer cell membranes, that is, cancer cells constantly repair their own cell ...
Views: 324 - New Approaches to Treating Neurological Diseases - by Submitted on Jun 09, 2021 from Jerry CarterA team led by medical researchers at Case Western Reserve University has developed a potential treatment for Perizois-metzbach's disease (PMD). It is a fatal neurological disease caused by genetic mutations that prevent the body from producing myelin, which is a protective insulator around nerve ...
Views: 322 - Clinical Progress of Anti-SARS-CoV-2 Neutralizing Antibody (NAb)—PART II - by Submitted on May 05, 2021 from Jerry CarterIn this article, we'll continue talking about the nAb drugs that have entered the clinical trials. LY-CoV555 and LY-CoV016 LY-CoV555 (also known as LY3819253, recently named bamlanivimab) is a fully human neutralizing IgG1 mAb developed by AbCellera and the National Institute of Allergy ...
Views: 317 - New Approaches to Coping with the Damage to Kidneys Caused by Excessive Intake of Processed Foods - by Submitted on Apr 28, 2021 from Jerry CarterA huge population consume large amounts of ready-to-eat foods such as bread, biscuits, and various snacks every day, which have been highly or overly heat-processed. During the processing, the chemical structure of the food is changed, thereby prolonging their shelf life, palatability, and ...
Views: 315 - Novel PROTAC, SPNpro - by Submitted on Jun 02, 2021 from Jerry CarterImmunometabolism involves glycolysis, tricarboxylic acid cycle, and pentose phosphate pathway and amino acid metabolism and other intracellular metabolic pathways, which play a vital role in regulating immune cell responses. In particular, the metabolism of amino acids such as tryptophan (Trp), ...
Views: 315 - The Fight Against Zika: PII - by Submitted on May 27, 2021 from Jerry CarterIn-progress Drugs There is an urgent need for broad-spectrum antiviral drugs to treat infections caused by emerging arboviruses. Some experts believe that one medicine for one type of vector insect is not enough to deal with outbreaks like the Zika pandemic. However, dozens of antiviral ...
Views: 313 - Surprising: An ancient virus hidden in the human genome provides a new target for esophageal cancer treatment - by Submitted on Jun 01, 2021 from Jerry CarterIn the human genome, about 8% of the DNA is the remnants of retroviruses that infect humans or human ancestors in ancient times, which have become part of the human genome. Some of these sequences can even be traced back to hundreds of millions of years ago. Previous studies have shown that ...
Views: 310 - Explore into Pharmacokinetics/pharmacodynamics (PK/PD) of Antibody Drugs - by Submitted on Mar 26, 2021 from Jerry CarterIn the past few decades, both pharmaceutical companies and academia have spent much financial resources and energy to improve the practicability and accuracy of in vitro screening technology that can test the biological activity and physicochemical properties of compounds. However, the study of ...
Views: 309 - ADCs Against Lung Cancer: PII - by Submitted on Jun 09, 2021 from Jerry CarterADC targeting Trop-2 Trophoblast cell surface antigen 2 (Trop-2) is a transmembrane glycoprotein encoded by the tumor-associated calcium signal transducer 2 (TACSTD2) gene located in the 1p32 region of chromosome, and is a new target for the treatment of solid tumors. It acts as a calcium ...
Views: 308 - Booster of Antibody Drug Discovery—Phage Display Library Technology - by Submitted on Apr 01, 2021 from Jerry CarterPhage display technology is a powerful gene expression screening technology, which was first described by SmithMl et al. in Science in 1985. The basic principle is to clone the gene of the foreign protein into the genomic DNA of the phage, thereby expressing the specific foreign protein on the ...
Views: 308 - Antibody screening technologies applied in innovative antibody discovery: PII - by Submitted on Jun 09, 2021 from Jerry CarterAntibody Library According to the source and use of antibody genes, antibody libraries are divided into immune antibody library (https://www.creative-biolabs.com/immune-antibody-library-services.html) and general antibody library. The antibody genes of the immune antibody library are derived ...
Views: 303 - Can HER3 Become a Therapeutic Target? - by Submitted on Jun 01, 2021 from Jerry CarterWith the increasingly fierce competition in the field of oncology drug R&D, the exploration of various drug forms based on established drug targets is a relatively low-risk R&D option. However, the commercialized drug targets that have been successfully operated are already very competitive. ...
Views: 301 - Progress! A Potential Drug to Treat Alzheimer's Disease (AD) - by Submitted on May 05, 2021 from Jerry CarterAlzheimer's disease is a neurodegenerative disease with insidious onset and progressive development, of which the clinical features are mainly cognitive impairment, abnormal mental behavior, and decline in social life function. Generally, early onset usually occurs before the age of 65. A family ...
Views: 300 - Comparison Between Phage Display Antibody Library and Hybridoma - by Submitted on Jun 02, 2021 from Jerry CarterAs commonly used antibody screening technologies, hybridomas and phage display (https://phagenbio.creative-biolabs.com/phage-display-systems.htm) libraries have their own characteristics. The heavy chain and light chain of hybridoma mAbs derive from a B cell, which is a natural pairing. The ...
Views: 299 - RNA Therapy—Center of Next-generation Innovative Therapies: Chapter II - by Submitted on Aug 03, 2021 from Jerry CarterThere are three key points in RNA drug R&D. First, the immunogenicity of RNA drugs: Because foreign RNA will be recognized by the immune system as a signal of virus interference, RNA drugs will more or less stimulate the immune system and cause a series of side effects. Second, the ...
Views: 297 - mRNA technology, not only plays a part in the COVID-19 vaccine but also in cancer therapeutics - by Submitted on Jun 01, 2021 from Jerry CarterIn the emergency response to the COVID-19 epidemic, the first vaccines to be released are all based on mRNA technology. Recently, the "double mutation" mutant virus appeared in India, and mRNA vaccine has once again been highlighted due to its short research cycle. Only a year ago, mRNA was ...
Views: 295 - RNA Therapy—Center of Next-generation Innovative Therapies: Chapter I - by Submitted on Jul 05, 2021 from Jerry CarterRNA drugs directly interfere with the process of gene transcription and translation, the essence of which is gene therapy. Traditional gene therapy in a narrow sense generally refers to directly modifying the disease-causing genes of target cells or introducing foreign copies of normal genes. ...
Views: 294 - 40 Billion USD Transactions, ADC Drugs Have Unlimited Potential - by Submitted on Apr 01, 2021 from Jerry Carter10 ADC drugs have been approved by the FDA for the treatment of various cancers including hematological tumors and solid tumors in a decade since 2010. Of the 10 ADC drugs currently on the market, 7 have been approved in the last three or four years. Such intensive approval has made ADC the ...
Views: 286 - ADCs Against Lung Cancer: PI - by Submitted on Jun 01, 2021 from Jerry CarterIn recent years, nanotechnology and nanotherapy have exerted a profound impact on many fields of medicine, of which the biggest contribution in cancer is mainly derived from the development of new drug delivery systems, including liposomes, nanoparticles, and antibody-drug conjugates (ADCs). ...
Views: 285 - Antibody screening technologies applied in innovative antibody discovery: PI - by Submitted on Jun 01, 2021 from Jerry CarterAntibody discovery includes two procedures, antibody screening and optimization. Antibody screening is to search for high-quality antibody candidates from the beginning, and antibody optimization is to make necessary improvements to existing antibodies. Antibody discovery is the only way to ...
Views: 275 - Organoid—Improve Disease Research and Drug Development - by Submitted on Feb 02, 2021 from Jerry CarterOrganoids, 3D "micro-organ models" that are prepared from different types of stem cells through self-organization, can simulate the structure and function of native organs. Organoids represent an innovative technology that covers the physiological processes of the entire organism, having a ...
Views: 271 - Why are many anti-cancer drugs effective in animals, but mediocre in humans? - by Submitted on Apr 28, 2021 from Jerry CarterPDX model (full name: patient-derived tumor xenograft model) is a transplanted tumor model formed by implanting patient-derived tumor tissue and primary cells into the body of immunodeficient mice. It is usually used to assist with testing and developing anti-cancer drugs. The PDX model ...
Views: 268 - Clinical Progress of Anti-SARS-CoV-2 Neutralizing Antibody (NAb)—PART III - by Submitted on May 26, 2021 from Jerry CarterIn this article, we'll continue talking about the nAb drugs that have entered clinical trial. REGN-COV2 REGN-COV2 is a new type of mixture composed of two mAbs (REGN10987 and REGN10933, recently named imdevimab and casirivimab, respectively) for the treatment of COVID-19 patients and the ...
Views: 264 - Why are many anti-cancer drugs effective in animals, but mediocre in humans? - by Submitted on Apr 28, 2021 from Jerry CarterPDX model (full name: patient-derived tumor xenograft model) is a transplanted tumor model formed by implanting patient-derived tumor tissue and primary cells into the body of immunodeficient mice. It is usually used to assist with testing and developing anti-cancer drugs. The PDX model ...
Views: 264 - CD38, a key depletion regulator molecule for CAR-T cells - by Submitted on Mar 29, 2024 from Jerry CarterIn recent years, CAR-T cell therapy has become one of the most promising treatments for hematologic malignancies and autoimmune diseases. The immunosuppressive environment and T-cell dysfunction that CAR-T cells face in vivo are the main factors contributing to suboptimal CAR-T cell therapy. ...
Views: 254 - The Fight Against Zika: PI - by Submitted on May 26, 2021 from Jerry CarterZika virus (ZIKV) is a new acute viral infectious disease mainly transmitted by Aedes mosquitoes. The clinical manifestations are usually mild, but some cases may develop serious symptoms such as neurological syndrome, birth defects, or stillbirth. The first reported case of human infection was ...
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