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Articles from Jerry Carter | Selfgrowth.com
- Putting the gas on the immune system! - by Submitted on Feb 07, 2022 from Jerry Carter"Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity", published by a team of researchers from the Massachusetts Institute of Technology (MIT) in Nature Biomedical Engineering on January 10, 2022. Attacking tumors by stimulating the ...
Views: 415 - Uncovering the mystery of the origin of Alzheimer's disease: Is the replication of prions in the human brain the culprit? - by Submitted on Oct 06, 2021 from Jerry CarterIn 1958, Francis Crick proposed the famous "Central Dogma", thereby constructing a large framework for the transmission of biological genetic information, namely "DNA→RNA→Protein". Of course, as a theory, the central principle is often questioned and misunderstood, e.g., RNA can also be written ...
Views: 415 - A major breakthrough has occurred! 99.9% safe contraceptive antibodies are now available - by Submitted on Oct 04, 2021 from Jerry CarterUnplanned pregnancy has always been a source of frustration, and researchers have worked diligently to create a range of contraceptive techniques. There are several types of contraception available for women, which may be described as hormonal contraception and barrier contraception. * ...
Views: 411 - New T-cell vaccine against SARS-CoV-2 mutant strains - by Submitted on Jun 25, 2023 from Jerry CarterA research team from China has developed an mRNA-based T-cell-inducing antigen vaccine that strengthens the COVID-19 vaccine against SARS-CoV-2 variants. Herd immunity through mass vaccination is an effective way to prevent infectious diseases. However, the common SARS-CoV-2 mutant strains ...
Views: 410 - Opportunities and Challenges of IVD - by Submitted on Feb 02, 2021 from Jerry CarterThe outbreak of the COVID-19 epidemic in 2020 brought unprecedented attention to the in vitro diagnostics (IVD) industry. At present, there are two main types of detection products for COVID-19 used internationally, which are molecular diagnosis (nucleic acid detection) and immunodiagnosis ...
Views: 410 - The endocytosis mechanism of ADC drugs: Part II - by Submitted on Oct 04, 2021 from Jerry CarterPit-mediated endocytosis Clathrin-independent endocytosis includes caveolin-mediated endocytosis, caveolin-independent carrier protein/GPI-enriched early inner compartment (CLIC/GEEC), and macropinocytosis. The pit is a vial-like invagination of the plasma membrane, characterized by high ...
Views: 408 - What is the severity of the Omicron mutation? - by Submitted on Jan 03, 2022 from Jerry CarterRecently, many scientists around the world summarized what they have learned about Omicron (an emerging variant of SARS-CoV-2) so far, as reported in Nature. Researchers from all over the world are now studying the Omicron strain to learn more about its infectivity, pathogenicity, and immune ...
Views: 407 - The evolutionary history of drug delivery - by Submitted on Aug 03, 2021 from Jerry CarterRecently, Samir Mitragotri's team published a review in Nature Biomedical Engineering, systematically summarizing five types of therapeutic drugs, which are small molecules, nucleic acids, peptides, proteins, and cells, as well as related drug delivery challenges and three measures taken to face ...
Views: 405 - Structure biology will continue to use artificial intelligence - by Submitted on Sep 02, 2021 from Jerry CarterNature issued an editorial on July 27, 2021, reflecting on recent topical reporting on AlphaFold. Our understanding of protein folding will be altered as a result of machine learning. It is important that all data be made available to the public. "I never imagined we'd make it this far in ...
Views: 404 - 10 Q&As About Monoclonal Antibody (mAb) - by Submitted on Mar 26, 2021 from Jerry CarterMonoclonal antibodies, mRNA/DNA vaccines, CAR-T cells, etc., are popular biological products nowadays, which play an important role in disease prevention and treatment. Most of these technologies originated in the 1980s, which are independent of each other and developed in concert to jointly ...
Views: 403 - What is Preclinical Testing? - by Submitted on Apr 01, 2021 from Jerry CarterIn the process of preclinical development, a compound or biological agent must go through the testing phases, for the following targets, which are the identification of potential targets of disease treatment and screening out the potential candidates that must go through toxicity test before ...
Views: 403 - Why Is ADC the "Rising Star of Cancer Treatment"? - by Submitted on Feb 02, 2021 from Jerry CarterIn the field of tumor therapy, antibody-drug conjugate (ADC) with both targeting and strong activities has gradually become the new focus of the industry due to its excellent performance in many indications, and it is known as "the rising star of tumor therapy". What is ADC Traditional ADC ...
Views: 402 - Uncovering the mystery of the origin of Alzheimer's disease: Is the replication of prions in the human brain the culprit? - by Submitted on Oct 06, 2021 from Jerry CarterIn 1958, Francis Crick proposed the famous "Central Dogma", thereby constructing a large framework for the transmission of biological genetic information, namely "DNA→RNA→Protein". Of course, as a theory, the central principle is often questioned and misunderstood, e.g., RNA can also be written ...
Views: 399 - The control of COVID-19 may require regular booster vaccinations - by Submitted on Jun 25, 2023 from Jerry CarterMost people today are immune to SARS-CoV-2, the coronavirus that causes COVID-19, thanks to widespread vaccination campaigns and unplanned infection. Although this widespread immunity hasn't stopped new infections from happening, it has slowed the devastating spread of illness and death that the ...
Views: 397 - 2020, the First Era of mRNA Therapy - by Submitted on Mar 02, 2021 from Jerry CarterCOVID-19 ravaged the world and caused huge losses to human society, but it has accelerated the research and development of mRNA drugs. Some people call 2020 "the first year of mRNA technology." Progress in mRNA drug development In 1990, Wolff et al. demonstrated for the first time that ...
Views: 396 - Another PROTAC entered clinical study - by Submitted on Jan 03, 2022 from Jerry CarterDecember 24, 2021—Accutar Biotechnology, a biotechnology company focused on AI drug development, announced that the FDA has approved its IND for AC0176 for the treatment of patients with metastatic decompensated refractory prostate cancer (mCRPC). AC0176 is an orally administered chimeric ...
Views: 395 - Understand the Hepatitis B - by Submitted on Apr 01, 2021 from Jerry CarterHepatitis B virus (HBV) infection is the leading cause of global morbidity and mortality. The WHO estimates that approximately 20 million people worldwide are infected with HBV. Among those chronically infected, it is estimated that 65 million people die of liver disease due to their HBV ...
Views: 394 - Clinical progress of hepatocellular carcinoma (HCC) treatment - by Submitted on Sep 02, 2021 from Jerry CarterHepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers. Globally, liver cancer is the fourth leading cause of cancer-related deaths and sixth in the number of new cases. The 5-year survival rate of liver cancer is only 18%, which is the second most lethal tumor after ...
Views: 393 - Immunogenicity of Antibody Drugs - by Submitted on Feb 03, 2021 from Jerry CarterThe advent of the era of precision medicine takes monoclonal antibody (mAb) drugs that have high specificity and effectiveness to a hot spot in biological drug therapy. In 1975, Georges Köhler and César Milstein successfully invented hybridoma technology, laying the foundation for monoclonal ...
Views: 391 - Evolution of Tumor Immunotherapy: PII - by Submitted on Aug 28, 2021 from Jerry CarterAnti-tumor Monoclonal Antibody (mAb) The concept that cancer cells express certain potential target antigens paves the way for humanized antibodies as a therapeutic strategy for malignant tumors. Antibodies can interact with immune cells through the Fc domain of antibodies to target and destroy ...
Views: 387 - New Modes of Antibody Drug Coupling—PDC, AOC, ABC, AAC, ISAC - by Submitted on Mar 26, 2021 from Jerry CarterIn recent years, antibody drugs have undergone explosive development and occupied an increasing proportion in the market of drugs. The high specific affinity of monoclonal antibody against tumor cell antigen making it an ideal carrier for targeted drug delivery, which can be used to target ...
Views: 387 - Evolutionary Drug Delivery - by Submitted on Sep 06, 2021 from Jerry CarterDrug delivery strategies (https://www.creative-biolabs.com/targeted-delivery/) have greatly facilitated the treatment and application of drugs. The rapid development of therapeutics is dependent on the continuous pursuit of advances in delivery technologies and strategies. Decades ago, small ...
Views: 377 - Interaction Among Phage, Bacteria, and Health-1 - by Submitted on Aug 04, 2021 from Jerry CarterAs bacterial viruses, bacteriophages have been increasingly reported for their unique role in affecting bacterial diseases. Bacteriophages (https://phagenbio.creative-biolabs.com/) can directly control the composition and abundance of bacteria and indirectly affect the body's metabolism and ...
Views: 377 - Stroke Cats Happily and Stay Away from Allergies - by Submitted on Mar 02, 2021 from Jerry CarterFor cat lovers, the most tragic thing is probably the cat allergy. As soon as you get close to the cat, you sneeze, have a runny nose, or itchy eyes, skin rashes, and even asthma attacks. There are many people who are allergic to cats, with about 1 in 10 in the population. In some areas, as ...
Views: 372 - Anti-HBV Drugs in Progress - by Submitted on Mar 26, 2021 from Jerry CarterHBV (https://www.creativebiolabs.net/symbolsearch_HBV.htm) generates free covalently closed circular DNA (cccDNA) and exists in the nucleus of infected cells, which is the only known pregenomic RNA (pgRNA) template, as well as a template for viral protein transcription and viral replication. As ...
Views: 371 - Ebola Comes Back, Another Blow Under the COVID-19 Epidemic - by Submitted on Mar 02, 2021 from Jerry CarterRecently, when most countries in the world are still struggling with the COVID-19, the Ebola virus (EBOV) that is more deadly, resurfaced. According to UN News, a funeral was held on February 1 after the death of a nurse in southern Guinea, West Africa, on January 28. Unfortunately, the 6 ...
Views: 371 - The amazing protein in the blood! - by Submitted on Aug 03, 2021 from Jerry CarterAlbumin (Alb: https://www.creativebiolabs.net/symbolsearch_ALB.htm) is the most important protein in human plasma, accounting for 40%-60% of total plasma protein, which can effectively maintain body nutrition and osmotic pressure, and is closely related to human health. Recently, a new study ...
Views: 369 - Firstly Uncovered Genetic Clues to Schizophrenia - by Submitted on Jan 03, 2022 from Jerry CarterCornel University researchers recently made a breakthrough in the study of schizophrenia with human-derived cerebral organoids. Schizophrenia is a chronic brain disorder of hitherto unknown exact etiology, with typical symptoms usually appearing in early adulthood and affecting approximately ...
Views: 366 - Recovered patients from COVID-19 contain super antibodies against 13 natural SARS-CoV-2 variants - by Submitted on Sep 02, 2021 from Jerry CarterAs the SARS-CoV-2 continues to mutate, virus variants and associated vaccine have become the focus of attention. On August 13, a study of a team of scientists who identified super antibodies from recovered patients, published in the prestigious journal Science, found that those patients carried ...
Views: 366 - Live Vaccines Against Malaria - by Submitted on Aug 04, 2021 from Jerry CarterFor a long time, malaria is one of the most serious diseases threatening human health. According to the WHO, there were 229 million clinical cases of malaria worldwide in 2019, and more than 400,000 people died from this disease. Although some countries have been confirmed by the WHO to ...
Views: 365 - A Quick Look at ADC—A New Favorite of Cancer Treatment - by Submitted on Feb 23, 2021 from Jerry CarterTraditional chemotherapeutics work by killing actively growing cells, but cannot accurately identify tumor cells. Therefore, when the tumor cells are killed, normal cells are also destroyed, resulting in larger adverse reactions. With the development of modern medicine, traditional extensive ...
Views: 364 - Collagen Lose Accelerates Cancer Development - by Submitted on Mar 26, 2021 from Jerry CarterCollagen is the most abundant protein in the human body, which is produced by fibroblasts and exists in bones, tendons, and skin. During the occurrence and development of cancer, collagen tends to accumulate in and around tumors. Therefore, some researchers speculate that collagen helps to ...
Views: 356 - Blockbuster—Rhesus Monkeys Produce Similar Immune Responses to Humans Against HCV - by Submitted on Apr 01, 2021 from Jerry CarterResearchers such as Mansun Law of The Scripps Research Institute discovered that rhesus monkeys can produce a convergent antibody response to HCV envelope glycoprotein. The paper entitled "Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques ...
Views: 354 - Released! Molecule Structure of ARV110 and ARV471 - by Submitted on Apr 28, 2021 from Jerry CarterA few days ago, Arvinas, which is committed to developing targeted protein degradation therapies, announced at the American Association for Cancer Research (AACR) annual meeting the molecular structure and pharmacochemical optimization process of two PROTAC based therapies entering the clinical ...
Views: 354 - Interaction Among Phage, Bacteria, and Health - by Submitted on Aug 28, 2021 from Jerry CarterWhat are the effects of bacteriophages on the body's immune system? Bacteriophages cannot infect eukaryotic cells, but more and more studies have shown that phages can regulate the immune response of mammals. Especially when the phage and the host bacteria ...
Views: 353 - A new, efficient protein delivery system may revolutionize gene therapy! - by Submitted on Jun 25, 2023 from Jerry CarterScientists from MIT and the Broad Institute have leveraged an existing bacterial system to create a novel strategy for protein delivery that is effective in both human and animal cells. This technique may be used to target certain cell types for the delivery of a wide range of proteins, ...
Views: 352 - Targeted protein degradation agent brings about another disruptive innovation - by Submitted on Aug 04, 2021 from Jerry CarterTraditional drug development strategies focus on how to treat diseases by directly regulating the activity of proteins or enzymes. Therefore, the development and application of protein activity regulators, especially inhibitors, has always been the mainstream of drug R&D. However, traditional ...
Views: 350 - "Super fungus" Infection Cases in ICU a Brazilian Hospital - by Submitted on Aug 04, 2021 from Jerry CarterRecently, a report published in the Journal of Fungi showed that the first cases of infection with the deadly super fungus Candida Auris (C. Auris) were found in the COVID-19 intensive care unit (ICU) of a Brazilian hospital. C. Auris ...
Views: 349 - First tRNA delivery via LNP brings new treatment modality for genetic diseases - by Submitted on Jun 25, 2023 from Jerry CarterNonsense mutations, which occur when a sense codon in a protein-coding sequence becomes a premature termination codon (PTC), are responsible for approximately 11% of human genetic diseases. The translational process of mRNA to protein is carried out by tRNA, which recognizes the codon on mRNA ...
Views: 348 - Detoxification matters! After some insects fully turn on the "detox mode", they can prolong their life by 21% - by Submitted on Sep 06, 2021 from Jerry CarterProtein is an important component of all cells and tissues of the human body. However, abnormal protein activities in the body may cause problems, such as increasing the risk of cancer and making people age faster. On July 28, a research report titled "Rewiring of the ubiquitinated proteome ...
Views: 345 - Cancer Neoantigen Vaccine R&D Contributes to Personalized Medicine - by Submitted on Jul 05, 2021 from Jerry CarterVaccines have traditionally been used to prevent infectious diseases, whose ability to induce and amplify antigen-specific immune responses has long been considered a potentially valuable tool for the treatment of cancer. Early therapeutic vaccination strategies focused on the abnormally ...
Views: 344 - Structural Insights into the G-Protein Specific Recognition Mechanism of the Human Glucagon Receptor - by Submitted on Jun 25, 2023 from Jerry CarterG protein-coupled receptors (GPCRs) play an important role in cellular signaling and serve as important therapeutic targets for a variety of diseases. Upon binding to extracellular agonists, GPCRs stimulate distinct signaling pathways by recruiting different G proteins (Gs, Gi, Gq, etc.,) to ...
Views: 344 - Challenges of Phage Therapy - by Submitted on Jul 04, 2021 from Jerry CarterIn this era of "superbugs" floods, phage therapy has re-entered public vision. Although there have been many cases of patients with "superbugs" infection being cured by phage, there are still some challenges in phage therapy. Quality and safety requirements The success of phage therapy ...
Views: 339 - Nature: An overview of the development of antibody drugs - by Submitted on Sep 02, 2021 from Jerry CarterIt has been 35 years since the FDA approved the first monoclonal antibody in 1986. Antibody-based drugs account for nearly one-fifth of new FDA drug approvals each year. In this time, antibody engineering (https://www.creative-biolabs.com/engineering-services.html) has changed dramatically. ...
Views: 339 - Design and optimization of PROTAC linking groups - by Submitted on Jul 05, 2021 from Jerry CarterSince the first proof of concept in 2001, targeted protein degradation induced by small molecules has gradually become a popular direction in drug development. There are two main strategies for inducing degradation. One is to use small molecules that can change the E3 ligase substrate ...
Views: 336 - AstraZeneca/Daiichi Sankyo launched phase III clinical study of antibody conjugate (ADC) Enhertu targeting HER2! - by Submitted on Aug 03, 2021 from Jerry CarterDaiichi Sankyo and AstraZeneca recently announced that in the global phase 3 clinical trial—DESTINY-The Gastric04 (NCT04704934), the first patient was given a drug treatment to evaluate the HER2-targeting ADC (https://www.creative-biolabs.com/adc/target-erbb2-37.htm) Enhertu (fam-trastuzumab ...
Views: 334 - Why are the results of cancer cell experiments always "different"? Cancer cells in a petri dish have nothing in common with cancer cells in the human body - by Submitted on Jul 05, 2021 from Jerry CarterCancer has always been one of the arch nightmares among all human diseases. It is also known as the "king of all diseases" because of its complexity and incurable nature. In order to find a cure for cancer, scientists often cultivate various cancer cell lines in a laboratory environment and ...
Views: 334 - PROTAC In Focus—Hotspot Targets Under Research - by Submitted on Apr 01, 2021 from Jerry CarterPROTAC is a novel type of drug that is different from antibodies and traditional small molecule inhibitors, consisting of a linker and two warheads. One end of the PROTAC molecule binds to the target protein, and the other binds to the E3 ubiquitin ligase that can mark the target protein as ...
Views: 331 - Breakthrough! A new target for pancreatic cancer treatment - by Submitted on Jun 02, 2021 from Jerry CarterPancreatic cancer is a highly malignant tumor of the digestive tract that is difficult to diagnose and treat. 90% of the subtypes are pancreatic ductal adenocarcinoma (PDAC). In recent years, the incidence and mortality of pancreatic cancer have increased significantly. The early diagnosis ...
Views: 330 - A Novel Type of Immunotherapy May Eliminate All Advanced Tumor Cells - by Submitted on Jul 04, 2021 from Jerry CarterImmunotherapy (https://www.creative-biolabs.com/immuno-oncology/) has gained full attention around the world, which gradually becomes the mainstream cancer treatment. As the key executor of the downstream effects of the immune response, macrophages play an important role in the immune response ...
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