The incidence rate of azoospermia is about 1%~2%, and 10%~15% is not very rare among infertile men. Thus, although the incidence rate seems very small, the male group with azoospermia is indeed in our real life.

Many common factors are causing male infertility, such as malnutrition, endocrine diseases, environmental impact, genetic deficiency, and so on. Among them, more than 30% of spermatogenesis disorders are caused by genetic deletion.

According to the research and analysis, a deletion region is related to azoospermia in the human Y chromosome species called the AZF region. This region contains multiple candidate genes related to spermatogenesis. In infertile men, the total deletion rate of the AZF region is 8.2%, which means that azoospermia occurs in the AZF region of Y chromosome species. Thus, genetic deletion is an essential cause of azoospermia.

For patients with obstructive azoospermia, determine whether it is caused by the vas deferens to hypoplasia or acquired vas deferens injury inflammation. A detailed understanding of whether there is a history of surgical trauma, sexually transmitted diseases, vas deferens, and other parts of the thorough examination can determine the obstruction or injury site.

For non-obstructive azoospermia, patients should receive targeted treatment with definite etiology. As we all know, the infected testis will damage the production function of sperm. In addition, if the inflammation spreads to adjacent organs such as the prostate and epididymis, causing prostatitis and epididymitis, sperm is easily injured, resulting in azoospermia. In this case, the first choice of drug treatment, common and effective herbal medicine Diuretic and Anti-inflammatory Pill.

In patients with obstructive azoospermia, restore the obstructed vas deferens by operation.

In addition to some of the hereditary causes of azoospermia, more and more men are caused by the acquired reasons. Therefore, please see what preventive measures are available!

1. Quit smoking

Smoking is a habit that most men have. However, a cigarette contains many harmful substances, which severely impact the reproductive cells in the testis. It will lead to the decline of sperm quality and decrease testosterone, thus causing sperm reduction and increasing the risk of azoospermia or oligospermia.

2. Avoid prolonged abstinence

Some men think that long-term abstinence can "nourish energy and accumulate energy." However, on the contrary, long-term abstinence will make genitals congested, and the scrotum temperature will rise. Sperm is more afraid of heat, and high temperatures will reduce its activity. Long-term abstinence will lead to sperm quality decline, which is not worth losing.

3. Caution in medication

Drugs often have side effects, especially for depression, malaria, or some blisters, affecting sperm production. So it would be best if you asked your doctor for advice when taking these drugs.

4. Prevent diseases that harm the male fertility

Some infectious diseases and venereal diseases will impact male fertility, such as reproductive tract infection. They have a significant lethality to sperm activity. Once infected, they will have an impact on sperm. Therefore, keep your health and avoid unprotected sexual life.


Although azoospermia is a complex and challenging disease, it does not mean giving up. After all, many people have had azoospermia and finally succeeded in having children. Early discovery and early treatment are the keys.

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