The incidence rate of azoospermia is about 1%~2%, and 10%~15% is not very rare among infertile men. Thus, although the incidence rate seems very small, the male group with azoospermia is indeed in our real life.

More than 30% of spermatogenesis disorders were caused by genetic deletion.

Many factors are causing male infertility, such as malnutrition, endocrine diseases, environmental impact, genetic deficiency, etc. More than 30% of spermatogenesis disorders are caused by genetic deletion.

According to the research and analysis, a deletion region is related to azoospermia in the human Y chromosome species called the AZF region. This region contains multiple candidate genes related to spermatogenesis. In infertile men, the total deletion rate of the AZF region is 8.2%, which means that azoospermia occurs in the AZF region of Y chromosome species. Thus, genetic deletion is an important cause of azoospermia.

How to diagnosis and treat azoospermia?

First of all, we need to understand that the etiology of azoospermia is quite complex. It is generally divided into two categories, namely obstructive azoospermia and non-obstructive azoospermia. The treatment is difficult because of its complex etiology, and the curative effect is poor. So, is it incurable?

Determine testicular function

If you want to treat azoospermia, you should first confirm whether the azoospermia is obstructive or non-obstructive, which will affect the follow-up treatment plan. The doctor can tell the types through illness inquiry, physical examination, and laboratory examination, then carry out treatment according to the test results.

Analyzed the etiology

In patients with non-obstructive azoospermia, history, experience, semen analysis, endocrine hormone, chromosomes, and other examinations are generally used to determine its pathogenic factors and use appropriate medicine according to the etiology. Many complex factors can cause testicular dysfunction. However, many patients can not find the cause through detailed examination, which can only be classified as idiopathic azoospermia.

For patients with obstructive azoospermia, determine whether it is caused by the vas deferens to hypoplasia or acquired vas deferens injury inflammation. A detailed understanding of whether there is a history of surgical trauma, sexually transmitted diseases, vas deferens, and other parts of the thorough examination can determine the obstruction or injury site.

Develop treatment plan

For non-obstructive azoospermia, patients should receive targeted treatment with definite etiology. As we all know, the infected testis will damage the production function of sperm. In addition, if the inflammation spreads to adjacent organs such as the prostate and epididymis, causing prostatitis and epididymitis, sperm is easily injured, resulting in azoospermia. In this case, the first choice is drug treatment, a typical and effective herbal medicine Diuretic and Anti-inflammatory Pill.

In patients with obstructive azoospermia, restore the obstructed vas deferens by operation.

Can men prevent the azoospermia caused by the acquired cause?

In addition to some hereditary causes of azoospermia, more and more men are caused by acquired reasons. Therefore, please see what preventive measures are available!

1. Quit smoking

Smoking is a habit that most men have. However, a cigarette contains many harmful substances, which severely impact the reproductive cells in the testis. It will lead to the decline of sperm quality and decrease testosterone, thus causing sperm reduction and increasing the risk of azoospermia or oligospermia.

2. Avoid prolonged abstinence

Some men think that long-term abstinence can "nourish energy and accumulate energy." However, on the contrary, long-term abstinence will make the genitals congested, and the scrotum temperature will rise. Sperm is more afraid of heat, and high temperatures will reduce its activity. Long-term abstinence will lead to sperm quality decline, which is not worth losing.

3. Caution in medication

Drugs often have side effects, especially for depression, malaria, or some blisters, affecting sperm production. So it would be best if you asked your doctor for advice when taking these drugs.

4. Prevent diseases that harm the male fertility

Some infectious diseases and venereal diseases will impact male fertility, such as reproductive tract infection. They have a significant lethality to sperm activity. Once infected, they will have an impact on sperm. Therefore, keep your health and avoid unprotected sexual life.


Although azoospermia is a complex and challenging disease, it does not mean giving up. After all, many people have had azoospermia and finally succeeded in having children. Early discovery and early treatment are the keys.

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